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KMID : 1144820180240010023
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대한의생명과학회지
2018 Volume.24 No. 1 p.23 ~ p.29
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Chitinase 3-Like 1 (CHI3L1) Polymorphism Contributes to Visceral Obesity and Obesity-related Inflammation Induces Chi3l1 in Adipocytes
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Kim A-Young
Jeong Hyun-Woo
Lee Ji-Hae
Choi Jin-Kyu
Kim Jeong-Kee
Hwang Jae-Sung
Seo Dae-Bang
Jeong Hyun-Woo
Lee Ji-Hae
Choi Jin-Kyu
Kim Jeong-Kee
Hwang Jae-Sung
Seo Dae-Bang
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Abstract
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Abdominal obesity is considered as one of the most risky factors governing the development of metabolic diseases. Here we identify that human chitinase 3-like 1 (CHI3L1, also called YKL-40 in human) single nucleotide polymorphism (SNP), rs883125, is associated with abdominal obesity in Korean women. Korean women subjects with the rs883125 G/G or C/G genotype present higher waist-hip ratio than subjects with C/C genotype suggesting that human subjects who G nucleotide substitution at the rs883125 tended to more accumulate intra-abdominal fat at the abdominal cavity. In addition, Chi3l1 gene expression is increased in adipose tissue from obese mice and pro-inflammatory cytokine enhances Chi3l1 expression in adipocytes, indicating that Chi3l1 is greatly related with obesity and obesity-induced pro-inflammatory responses. Taken together, the minor allele of rs883125 is associated with a higher prevalence of abdominal obesity in Korean women. These findings suggest that genotype of rs883125 can be a biomarker of incident abdominal obesity and abdominal obesity-related metabolic diseases.
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KEYWORD
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Chitinase 3-like 1, CHI3L1, YKL-40, SNP, Abdominal obesity, Korean women
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